Avant Labs - Avant Labs LipoDerm-Y 4 oz Bottle

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Avant Labs LipoDerm-Y 4 oz Bottle

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Now with CaffeineLipoDerm-Y is the most significant breakthrough in fat loss products to date. Containing the alpha 2 receptor antagonist Yohimbine Hydrochloride in Avant Labs Patent Pending hydroalcoholic gel, Lipoderm-Y releases large amounts of fat from the sites of applicationfar higher than is possible with alternate administration methodswhile avoiding the negative side effects associated with systematic distribution. Coupled with a caloric deficit, Lipoderm-Y s targeted delivery accelerates localized fat loss in those typically stubborn areas, such as a womans lower body or a mans midsection. Lipoderm-Y makes what was once the myth of spot reduction a scientifically-proven reality. Each 4oz bottle contains 18-30 applications, with 3 grams of Yohimbine HCl per bottle. Topical Fat Loss Solution I have previously stated that I believe transdermal prohormones to be the most effective supplements ever to hit the market. That statement must now be amended. Transdermal prohormones are indeed the most effective MUSCLE BUILDING supplements ever to hit the market. But, topical fat loss products have the potential to be an even bigger overall breakthrough in the never ending quest to improve body composition. There are four areas that need to be addressed in regards to topical fat loss products and so called spot reducers in general. First, one needs to distinguish between the products that are merely diuretics and those that the manufacturer assuming they have a brain actually thinks might significantly reduce body fat. Second, we have to have an understanding of the andrenergic system, which is primarily what these products attempt to manipulate in order to aid lipolysis Thirdly, we must have an understanding of transdermalpercutaneous delivery, in order to understand why a topical formulation could present advantages vs. orals, as well as to understand why every product of this kind currently on the market, other than LipoDerm-Y, fails. Within this category there are 2 issues -- getting adequate amounts past the skin barrier and localizing its distribution to adipose tissue. And, finally, there is the issue of Yohimbine HCl vs. yohimbe. After reading this, you should have an understanding of why true spot reduction is physiologically quite possible, as well as enough information to make an informed decision as to which products can and cannot accomplish it. Fat Loss Agents vs. Diuretics Assuming we are not preparing for a photoshoot or competition, a product that merely acts as a diuretic rather than significantly aiding actual lipolysis is basically worthless. Cutting Gel belongs in this category -- its active ingredient is aminophylline: Aminophylline is a xanthine derivative, similar to caffeine, which is not a particularly potent fat burner. In rat studies, it has shown good thermogenic properties due to blockade of adenosine receptors which provide one of the negative feedback mechanisms for catecholamine induced thermogenesis and inhibition of phosphodiesterase which degrade cyclic AMP -- but this is at extremely high doses, which would kill a human, so it is not applicable 1,2. At therapuetic doses, only adenosine blockade occurs, which will act to increase norepinephrine levels 3-- but as you will see norepinephrine stimulates alpha 2 receptors bad in addition to beta 2 receptors good -- and in stubborn fat, alpha 2's outnumber beta 2's 4. Like caffeine, it is a good diuretic 5, which would account for the girth loss in the study they reference, which did not measure actual fat loss 6,7. One study did look at fat depth after use of an aminophylline cream, and no difference was found vs. control 8. As a local diuretic, it might be effective, but as a true fat loss agent, it quite likely is not. Precontest, such a product could be extremely beneficial if it would truly localize the water loss, as it would allow one to get rid of extracellular water with out the total body dehydration produced by drugs such as Lasix -- thus, one could have fuller muscles, less cramping, etc. I am not particularly familiar with the physiology of diuresis, as I have not researched it to any great extent, so I don't know if it could actually be localized. Products such as LipoDerm-Y, Impact's DermaLean, and S.A.N.'s LipoBurn basically any of the products with yohimbine and a handful of other ingredients fall into the latter category. They are intended to manipulate the adrenergic system, thus, theoretically, such products could cause true localized fat loss if formulated properly: The Adrenergic System Introduction One of the major contributors to body weight homeostasis in the human body is the adrenergic system. There are two types of adrenergic receptors, alpha and beta, as well as subtypes of each -- and depending on which are activated, lipolysis breakdown of fat can be either stimulated or inhibited. The most well-known adrenoreceptors to bodybuilders are the beta receptors. These can be divided into subtypes 1, 2, and 3 -- and it is through these receptors that drugs such as the ephedrinecaffeine stack and Clenbuterol exert their effects. While Clenbuterol acts directly on beta 2 receptors, ephedrine exerts its effects indirectly by stimulating the release of norepinephrine NE, the body's primary endogenous thermogenic hormone. Unlike Clenbuterol, NE is not selective in its binding. In addition to binding to the beta 2 receptor, it also binds to both alpha receptors, as well as the beta 1 and 3 receptors. It is in regards to its binding to the alpha 2 receptor that yohimbine comes into play. Norepinephrine and Yohimbine Activation of the alpha 2 receptor inhibits the release of NE. Thus, by binding to this receptor, NE functions as its own negative feedback signal. In other words, it shuts off its own release. Obviously, this is not a good thing for fat loss. This is particularly true at rest which, unless you are a marathon runner is 95% of your day -- this is because alpha 2 receptors are activated at lower catecholamine levels than are the beta receptors 9. Thus, thermogenesis is basically always turned off. It is the differences in regional distribution of alpha 2 and the beta receptors that is responsible for the gender differences in bodyfat storage 4. Basically, females have a large number of alpha 2 receptors and few beta receptors in the gluteofemoral area hips, thighs, and butt, while men have the same problem in the midsection. With exercise or the use of compounds such as the ephedrinecaffeine stack, catecholamine levels can be increased to a point where the alpha 2 induced inhibition of lipolysis is partially overcome 9. However, even then, the alpha 2 receptors ARE still acting to reduce lipolysis. Yohimbine is a selective alpha 2 antagonist 10 and can thus short circuit this feedback loop, maximizing NE levels, thus maximizing fat loss, particularly in these problem areas -- and even more so if we can achieve high levels of yohimbine and NE in the adipose tissue. Unfortunately, to do so with orals, or any other method that results in high blood levels means that we will also have high levels in the heart and CNS -- thus, we will also have unpleasant and dangerous side effects. Considering the subject of this article, I obviously believe the solution lies in transdermal administration, but more on that in a bit. Blood Flow A second, more indirect, mechanism by which Yohimbine can aid lipolysis via the adrenergic system is by increasing peripheral blood flow 11, 12. Adipose tissue is known to have rather poor vascularity. When triglycerides are broken down into free fatty acids and glycerol during lipolysis, they must also be transported away from the fat cell or they risk being reincorporated into adipose tissue. Beta receptor activation causes vasodilation, thus increasing blood flow, however, it does not increase enough to remove all of the free fatty acids released during lipolysis 13. Alpha 1 and 2 receptor activation, on the other hand, causes a decrease in blood flow 4, 14. Thus, antagonism of the alpha 2 receptor with yohimbine would be expected to increase blood flow, and thus increase the mobilization and disposal of these FFA's, further aiding fat loss. And, again, the more we can get in the adipose tissue without it reaching the heart and CNS, the better. Percutaneous Delivery Though the terms are often used interchangeably in the literature, there are two distinct forms of drug delivery through the skin. The first, and most common, is Transdermal Delivery -- this involves a drug bypassing the skin barrier in order to be taken up into the bloodstream and distributed systemically 15. This basically does the same thing as oral delivery, but it is inherently time released and avoids first pass metabolism in the liver which can limit bioavailability and cause hepatotoxicity, so it is is advantageous for delivering many drugs. The second i

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